國際性重要臨床試驗摘要        回醫護專區

  肺癌
A Randomized Placebo-Controlled Trial of Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) Following Failure of 1st Line or 2nd Line Chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) Trial 950519
Mediastinal Lymph Node Clearance After Docetaxel-Cisplatin Neoadjuvant Chemotherapy Is Prognostic of Survival in Patients With Stage IIIA pN2 Non-Small-Cell Lung Cancer: A Multicenter Phase II Trial
Randomized phase III study of docetaxel (D) versus vinorelbine (V) for elderly patients (pts) with advanced non-small cell lung cancer (NSCLC): Results of a West Japan Thoracic Oncology Group trial (WJTOG9904)
Phase III Randomized Trial of Docetaxel Plus Cisplatin Versus Vindesine Plus Cisplatin in Patients With Stage IV Non-Small-Cell Lung Cancer: The Japanese Taxotere Lung Cancer Study Group
A randomized phase III trial of paclitaxel plus carboplatin with or without bevacizumab in patients with advanced non-squamous non-small cell lung cancer950609
Determinants of Tumor Response and Survival with Erlotinib in Patients with Non-Small-Cell Lung Cancer950707
Randomized, Multinational, Phase III Study of Docetaxel Plus Platinum Combinations Versus Vinorelbine Plus Cisplatin for Advanced Non-Small-Cell Lung Cancer: The TAX 326 Study Group950728

  乳癌
A randomized phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first line therapy for locally recurrent or metastatic breast cancer950526
Trastuzumab in adjuvant breast cancer950331
Effective and safety of Trastuzumab combined with Docetaxel in Patients with human epidermal growth factor receptor 2- positive metastatic breast cancer administrated as first line treatment 950324
Herceptin in adjuvant breast cacner950310
Effective and safety of Trastuzumab as single agent in first line treatment of Her2-overexpressing metastatic breast cancer 950303
Multinational study of efficacy and safety of humanized anti-Her2 monoclonal antibody in women who have Her2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease 950224
Use of chemotherapy plus a monoclonal antibody againt her2 for metastatic breast cancer that overexpresses her2950210
Significantly higher pathology complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel and epirubicin chemotherapy: Results a randomized trial in human epidermal growth facter receptor-2 positive breast cancer950127
Trastuzumab in adjuvant breast cancer950106
Postoperative dose-dense sequential chemotherapy with epirubicin, followed by CMF with or without paclitaxel, in patients with high-risk operable breast cancer: a randomized phase Ⅲ study conducted by the Hellenic Copperative Oncology Group950106
Phase Ⅲ trial of epirubicin plus paclitaxel compared with epirubicin plus cyclophosphamide as first-line chemotherapy for metastatic breast cancer
Randomized Phase III Study of Docetaxel Compared With Paclitaxel in Metastatic Breast Cancer
Adjuvant Docetaxel for Node-Positive Breast Cancer
Docetaxel and Doxorubicin Compared With Doxorubicin and Cyclophosphamide as First-Line Chemotherapy for Metastatic Breast Cancer: Results of a Randomized, Multicenter, Phase III Trial

大腸直腸癌
Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (mCRC)970111
Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer (mCRC)970111
Impact on quality of life of adding cetuximab to irinotecan in patients who have failed prior oxaliplatin-based therapy970111
Infusion-related reactions (IRR) associated with cetuximab plus irinotecan treatment in patients with irinotecan-resistant metastatic colorectal cancer (mCRC)970111
Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data.970111
Randomized Phase III trial of cetuximab monotherapy plus best supportive care (BSC) versus BSC alone in patients with pretreated metastatic epidermal growth factor receptor (EGFR)-positive colorectal carcinoma: A trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) and the Australasian Gastro-Intestinal Trials Group (AGITG)970111
Oxaliplatin/5FU/LV in the adjvvant treatment of stage II and stage III colon cancer: efficacy results with a median follow-up of 4 years
A phase III trial comparing FULV to FULV + oxaliplatin in stage II or III carcinoma of the colon: Results of NSABP Protocol C-07
Leucovorin and Fluorouracil With or Without Oxaliplatin
as First-Line Treatment in Advanced Colorectal Cancer
High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200.
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
High-dose Bevacizumab in Combination with FOLFOX4 Improve Survival in Patients with Previously950602
Bevacizumab plus Irinotecan, Fluorouracil and Leucovorin for Metastatic Colorectal Cancer950623
Capecitabine (Xeloda) vs bolus 5-FU/Leucovorin (LV) as adjuvant therapy for colon cancer950714
A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients With Previously Untreated Metastatic Colorectal Cancer950721

胃癌
Phase II study of weekly oxaliplatin and 24-h infusion of high-dose
5-fluorouracil and folinic acid in the treatment of advanced gastric
cancer
Phase II Study of Oxaliplatin, Fluorouracil, and Folinic Acid
in Locally Advanced or Metastatic Gastric Cancer Patients

  前列腺癌
Docetaxel plus Prednisone or Mitoxantrone plus Prednisone for Advanced Prostate Cancer
Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer

  白血病
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for Chronic Lymphocytic Leukemia950407
Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory Chronic Lymphocytic Leukemia950421

  淋巴瘤
Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte950505
CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma950512
   

  胰臟癌
Erlotinib Improves Survival When Added to Gemcitabine in Patients with Advanced Pancreatic Cancer. A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) 950630
   

  其他
Anagrelide, a Therapy for Thrombocythemic States:
Experience in 577 Patient